Agents thérapeutiques émergents dans le traitement du lymphome diffus à grandes cellules B, récidivant ou réfractaire
Résumé
Le lymphome diffus à grandes cellules B (LDGCB) est le type le plus fréquent de lymphome non hodgkinien (LNH) agressif. L’âge médian au moment du diagnostic du LDGCB est de 65 ans, et environ un tiers des patients ont plus de 75 ans lors du diagnostic. Le standard pour le traitement de première ligne est l’immuno-chimiothérapie, composée de rituximab, de cyclophosphamide, de doxorubicine, de vincristine et de prednisone (R-CHOP). Bien que 60 % des patients sont guéris avec ce traitement standard, mais il est inaccessible pour environ 25 % des patients en raison de l’âge avancé et des comorbidités sous-jacentes, y compris le dysfonctionnement cardiaque. Quelques facteurs biologiques confèrent un risque d’échec du traitement, notamment la cellule d’origine B activée (ABC), et un phénotype de double expression (c’est-à-dire une surexpression de c-MYC et BCL-2).
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