Emerging therapeutic agents in the treatment of relapsed or refractory diffuse large B cell lymphoma
DOI:
https://doi.org/10.58931/cht.2022.1110Abstract
Diffuse large B cell lymphoma (DLBCL) is the most common type of aggressive non-Hodgkin lymphoma (NHL). The median age at diagnosis of DLBCL is 65, and about one-third of patients are older than age 75 at diagnosis. The standard of care for frontline treatment is chemoimmunotherapy, consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (RCHOP). Approximately 60% of patients are cured with standard treatment, but it is inaccessible for up to 25% of patients due to advanced age and underlying comorbidities, including cardiac dysfunction. Several biologic factors confer risk of treatment failure, including activated B cell (ABC) cell of origin and double expressor phenotype (i.e. and overexpression of c-MYC and BCL2).
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