Bruton Tyrosine Kinase Inhibitors for B-Cell Malignancies


  • Christopher Lemieux, MD, FRCPC CHU de Québec-Université Laval, Laval, Québec


Over the last 10 years, Bruton Tyrosine kinase inhibitors (BTKi) have been a significant breakthrough for the treatment of B-cell malignancies, especially in chronic lymphocytic leukemia (CLL). Since the initial publication of the activity of ibrutinib in 2013, many publications have highlighted the improved outcomes for patients with B-cell malignancies owing to the use of ibrutinib and other BTKi. BTKi monotherapy has been standard of care for many years and more recently, combination therapies that include targeted therapy or chemotherapy are being studied.

Author Biography

Christopher Lemieux, MD, FRCPC, CHU de Québec-Université Laval, Laval, Québec

Dr. Christopher Lemieux is a Hematologist at the CHU de Québec-Université Laval. He completed specialized training in transplantation and cell therapy at Stanford University in California, for which he received the Detweiler scholarship from the Royal College of Physicians and Surgeons of Canada and the Stephen Couban prize of the Canadian Hematology Society. He is currently director of the CAR-T program at the CHU de Québec-Université Laval and is a member of the immunocellular therapy network in Québec. He is a Clinical Associate Professor of Medicine and director of the Hematology fellowship program at Université Laval.


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How to Cite

Lemieux C. Bruton Tyrosine Kinase Inhibitors for B-Cell Malignancies. Can Hematol Today [Internet]. 2024 Feb. 26 [cited 2024 Jul. 23];3(s02):3–7. Available from:

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