Cellular therapy in CLL/iNHL: Therapeutic agents in the pipeline


  • Christopher Lemieux, MD, FRCPC CHU de Québec-Université Laval




Advanced cellular therapies have been introduced in Canada over the past two years. Chimeric antigen receptor (CAR) T-cell therapy is the current standard of care for third-line large B-cell lymphoma (LBCL), relapsed/ refractory (RR) acute lymphoblastic leukemia (ALL) in patients < 26 years old and, more recently, in third-line mantle cell lymphoma. These novel therapies are now gaining more prominence in the treatment of LBCL with recent FDA approval for the second line in patients eligible for stem cell transplant, based on recent Phase 3 trials. Another class of novel immunotherapy agents are bispecific T-cell engagers (BiTEs) which have been studied in many B-cell malignancies but are not yet approved in Canada.

The indolent non-Hodgkin’s lymphoma (iNHL) and chronic lymphocytic leukemia (CLL) landscape have been evolving over the past few years with many novel therapies being studied and becoming available. However, patients with RR iNHL, as well as patients using Bruton tyrosine kinase (BTK) and B-cell lymphoma-2 (BCL2) inhibitors for refractory CLL continue to have an unmet need for treatment. This article will focus on cellular therapy that will likely be available for use by Canadian clinicians in the near future to treat patients with iNHL and CLL.

Author Biography

Christopher Lemieux, MD, FRCPC, CHU de Québec-Université Laval

Dr. Christopher Lemieux is a Hematologist at the CHU de Québec-Université Laval. He completed specialized training in transplantation and cell therapy at Stanford University in California, for which he received the Detweiler scholarship from the Royal College of Physicians and Surgeons of Canada and the Stephen Couban prize of the Canadian Hematology Society. With this experience, he is currently director of the CAR-T program at the CHU de Québec-Université Laval and is a member of the immunocellular therapy network in Québec. He is a Clinical Associate Professor of Medicine and director of the Hematology fellowship program at Université Laval.


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How to Cite

Lemieux C. Cellular therapy in CLL/iNHL: Therapeutic agents in the pipeline. Can Hematol Today [Internet]. 2023 Jun. 7 [cited 2024 Apr. 15];2(2):12–14. Available from: https://canadianhematologytoday.com/article/view/2-2-lemieux




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