Treatment of Philadelphia Chromosome-negative Myeloproliferative Neoplasms in 2024: A Concise Review

Authors

  • Akhil Rajendra, MD, DM Clinical Research Fellow, Leukemia and Myeloproliferative Neoplasm, Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto
  • Dawn Maze, MD, FRCPC, MSc Division of medical oncology and hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada

DOI:

https://doi.org/10.58931/cht.2024.3357

Abstract

In 1951, William Dameshek coined the term myeloproliferative disorders (MPDs) for diseases characterized by abnormal proliferation of one or more terminally differentiated myeloid cell lines in the peripheral blood.1,2 In 2008, the World Health Organization (WHO) renamed these disorders as myeloproliferative neoplasms (MPNs) in recognition of their clonal nature. There are currently two classification system for MPNs: WHO and International Consensus Classification (ICC), 2022.3,4 This review will focus on the Philadelphia chromosome-negative MPNs, which include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF).

Author Biographies

Akhil Rajendra, MD, DM, Clinical Research Fellow, Leukemia and Myeloproliferative Neoplasm, Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto

Dr. Akhil Rajendra is a Clinical Research fellow in the Leukemia and Myeloproliferative neoplasms program at the Princess Margaret Cancer Centre, University of Toronto. Prior to coming to Toronto, he obtained his M.D. in internal medicine at Christian Medical College, Vellore, India. He completed his subspecialty training in medical oncology and haemato-oncology at Tata Memorial Hospital, Mumbai, India. He has a special interest in acute leukemias and myeloid disorders.

Dawn Maze, MD, FRCPC, MSc, Division of medical oncology and hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada

Dr. Dawn Maze is a clinician investigator at the Princess Margaret Cancer Centre and an Assistant Professor in the Department of Medicine at the University of Toronto. She is a member of the Leukemia Site Group and the Myeloproliferative Neoplasms (MPN) Program and has a clinical research interest in myeloid malignancies. Her primary research focus is in MPN, particularly in risk stratification and management approaches early in the disease course and in the adolescent/young adult population. She is particularly interested in optimizing pregnancy outcomes in this population. She is also actively involved in clinical trials and projects aiming to refine risk stratification in acute myeloid leukemia. Dr. Maze is an active member of the Canadian MPN Group. She is the Medical Director for the Malignant Hematology Day Unit at Princess Margaret and the Program Director for the Leukemia Fellowship Program.

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2024-12-03

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Rajendra A, Maze D. Treatment of Philadelphia Chromosome-negative Myeloproliferative Neoplasms in 2024: A Concise Review. Can Hematol Today [Internet]. 2024 Dec. 3 [cited 2024 Dec. 21];3(3):19–31. Available from: https://canadianhematologytoday.com/article/view/3-3-Rajendra_et_al

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