Nouvelles avancées dans le traitement de première ligne du lymphome de Hodgkin classique de stade avancé : une perspective canadienne

Auteurs-es

  • Jowon L. Kim, M.D.
  • Kerry J. Savage, M.D.

Résumé

Le lymphome de Hodgkin classique (LHc) est hautement guérissable, avec d’excellents résultats obtenus grâce à des décennies d’amélioration des traitements. Ces dernières années ont été marquées par un changement de paradigme dans la prise en charge des patients atteints d’une maladie de stade avancé, grâce à l’intégration de nouvelles thérapies dans le traitement de première ligne. La réduction des complications à long terme reste un objectif important, en particulier pour les patients adolescents et les jeunes adultes. Nous résumerons ici les derniers développements dans le traitement du LHc de stade avancé d’un point de vue canadien, en nous concentrant sur les essais cliniques récents qui ont redéfini le paysage thérapeutique.

Biographies de l'auteur-e

Jowon L. Kim, M.D.

La Dre Kim est boursière postdoctorale (fellow) en lymphome à la Mayo Clinic Rochester. Elle a obtenu son diplôme de médecine et suivi une formation en médecine interne et en hématologie à l’Université de Colombie-Britannique. Ses recherches cliniques portent principalement sur le lymphome de Hodgkin, et elle s’intéresse particulièrement à l’affinement des groupes à risque afin d’orienter le choix du traitement optimal à l’ère des nouvelles thérapies.

Kerry J. Savage, M.D.

La Dre Kerry Savage est oncologue médicale au BC Cancer et professeure de médecine (aspirante à la permanence) à l’Université de la Colombie-Britannique (UBC). Elle est titulaire d’un baccalauréat en sciences (B.Sc.) (biologie [génétique]) et d’un doctorat en médecine de l’UBC. Elle a effectué un stage de recherche postdoctoral sur les lymphomes au Dana-Farber Cancer Institute de Boston au Massachusetts, et a obtenu une maîtrise (M.Sc.) en épidémiologie à la Harvard School of Public Health. Elle est responsable de l’unité du groupe d’essais cliniques sur le lymphome, le myélome et le mélanome du BC Cancer Vancouver. Elle siège au comité consultatif scientifique de la Lymphoma Research Foundation et de Lymphome Canada. Elle est actuellement rédactrice en chef adjointe de la revue Haematologica. Les domaines de recherche de la Dre Savage comprennent les lymphomes périphériques à cellules T, le lymphome de Hodgkin et le lymphome médiastinal primitif à grandes cellules B, y compris la recherche chez les adolescents et les jeunes adultes, et l’étude des facteurs prédictifs de récidive au système nerveux central dans le lymphome diffus à grandes cellules B.

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Publié

2025-12-08

Comment citer

1.
Nouvelles avancées dans le traitement de première ligne du lymphome de Hodgkin classique de stade avancé : une perspective canadienne . Can Hematol Today [Internet]. 8 déc. 2025 [cité 21 avr. 2026];4(3):5–17. Disponible à: https://canadianhematologytoday.com/article/view/4-3-Kim_et_al

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Comment citer

1.
Nouvelles avancées dans le traitement de première ligne du lymphome de Hodgkin classique de stade avancé : une perspective canadienne . Can Hematol Today [Internet]. 8 déc. 2025 [cité 21 avr. 2026];4(3):5–17. Disponible à: https://canadianhematologytoday.com/article/view/4-3-Kim_et_al