New Developments in the Front‑line Treatment of Advanced Stage Classic Hodgkin Lymphoma: A Canadian Perspective

Authors

  • Jowon L. Kim, MD Division of Hematology, University of British Columbia, Vancouver, B.C.
  • Kerry J. Savage, MD Centre for Lymphoid Cancer and Division of Medical Oncology, BC Cancer, Vancouver, B.C.

DOI:

https://doi.org/10.58931/cht.2025.4377

Abstract

Classic Hodgkin lymphoma (cHL) is highly curable, with excellent outcomes achieved through decades of treatment refinement. Recent years have witnessed a paradigm shift in the management of patients with advanced stage disease, driven by the integration of novel therapies into front-line treatment. Minimizing long-term complications remains an important objective, especially for patients in the adolescent/young adult (AYA) age group. Herein, we summarize the latest developments in the treatment of advanced stage cHL through a Canadian lens, focusing on recent clinical trials that have reshaped the therapeutic landscape.

Author Biographies

Jowon L. Kim, MD, Division of Hematology, University of British Columbia, Vancouver, B.C.

Dr. Kim is a lymphoma fellow at Mayo Clinic Rochester. She obtained her medical degree and completed Internal Medicine and Hematology training at the University of British Columbia. Her clinical research focus is in Hodgkin lymphoma, with an interest in further refining risk groups to guide optimal treatment selection in the era of novel therapies.

Kerry J. Savage, MD, Centre for Lymphoid Cancer and Division of Medical Oncology, BC Cancer, Vancouver, B.C.

Dr. Kerry Savage is a Medical Oncologist at BC Cancer and a Professor of Medicine (tenure track) at the University of British Columbia (UBC). She received a BSc (Biology (Genetics) and a M.D. from UBC. She completed a post-doctoral research fellowship in lymphoma at the Dana-Farber Cancer Institute in Boston, MA, and earned a MSc in Epidemiology from the Harvard School of Public Health. She is the Business Unit Leader for the lymphoma/myeloma and melanoma BC Cancer Vancouver clinical trial group. She is on the Scientific Advisory Board for the Lymphoma Research Foundation and Lymphoma Canada. She is currently an Associate Editor at Haematologica. Dr. Savage’s research interest areas include peripheral T-cell lymphomas, Hodgkin lymphoma and primary mediastinal large B-cell lymphoma including research in the AYA age group, as well as investigating predictors of central nervous system relapse in diffuse large
B-cell lymphoma.

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2025-12-08

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Kim JL, Savage KJ. New Developments in the Front‑line Treatment of Advanced Stage Classic Hodgkin Lymphoma: A Canadian Perspective. Can Hematol Today [Internet]. 2025 Dec. 8 [cited 2025 Dec. 12];4(3):5–17. Available from: https://canadianhematologytoday.com/article/view/4-3-Kim_et_al

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