Front-line Treatment of B-cell Acute Lymphoblastic Leukemia in Canada: Current Strategies and Evolving Paradigms

Authors

  • Curtis Marcoux, MD Division of Hematology, Dalhousie University, Halifax, Canada

DOI:

https://doi.org/10.58931/cht.2025.4165

Abstract

The treatment landscape for adults with B-cell acute lymphoblastic leukemia (B-ALL) has evolved considerably, with pediatric-inspired regimens, targeted therapies, and measurable residual disease (MRD)-guided approaches improving outcomes. However, treatment strategies in the clinic remain highly variable due to heterogeneity in prospective trials, a lack of randomized comparative data, and the continued evolution of therapies—particularly with the increasing use of targeted agents and immunotherapies in the front-line setting. The absence of national standardization further contributes to variability in clinical practice.

This review provides an overview of current front-line treatment strategies for B-ALL in Canada, highlighting key therapeutic approaches and recent advancements in optimizing care.

Author Biography

Curtis Marcoux, MD, Division of Hematology, Dalhousie University, Halifax, Canada

Dr. Curtis Marcoux is an Assistant Professor at Dalhousie University and a hematologist in the Division of Hematology at Nova Scotia Health. He earned his MSc from the University of Ottawa and completed his medical training at Memorial University of Newfoundland. He pursued hematology training at Dalhousie University, followed by a fellowship in Stem Cell Transplantation and Cellular Therapy at MD Anderson Cancer Center in Houston, Texas. His clinical and research interests focus on stem cell transplantation, cellular therapies, and acute leukemia.

References

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Published

2025-05-05

How to Cite

1.
Marcoux C. Front-line Treatment of B-cell Acute Lymphoblastic Leukemia in Canada: Current Strategies and Evolving Paradigms. Can Hematol Today [Internet]. 2025 May 5 [cited 2025 Jun. 1];4(1):28-35. Available from: https://canadianhematologytoday.com/article/view/4-1-Marcoux_et_al

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Section

Articles