Frontline treatment of aggressive B-cell lymphoma


  • Shannon Murphy, MD Dalhousie University, Halifax, NS



Aggressive B-cell non-Hodgkin lymphoma, which most often manifests as diffuse large B-cell lymphoma (DLBCL), is the most common non-Hodgkin lymphoma, accounting for up to 30% of diagnosed cases. It is responsible for considerable morbidity and mortality worldwide, with a global burden of approximately 150,000 new patients annually. Large B-cell lymphoma encompasses a group of lymphomas with significant clinical and biological heterogeneity. While there are approximately 18 variations of large B-cell lymphoma in the upcoming 5th edition of the World Health Organization classification of lymphoid neoplasms (WHO-HAEM5), for the purposes of this review the aggressive B-cell lymphomas will refer to the most common entity, diffuse large B-cell lymphoma, not otherwise specified (DLBCL), as well as diffuse large B-cell lymphoma/high-grade B-cell lymphoma with MYC and BCL2 rearrangements (DLBCL/HGBL-MYC/BCL2), and high-grade B-cell lymphoma, not otherwise specified (HGBL,NOS).

Author Biography

Shannon Murphy, MD, Dalhousie University, Halifax, NS

Dr. Shannon Murphy is a Hematologist and Assistant Professor at Dalhousie University and practices at the QEII Health Sciences Centre in Halifax, NS. Prior to joining the Division of Hematology and Hematologic Oncology in Halifax, Dr. Murphy completed her internal medicine and hematology training at Dalhousie University, followed by a 1-year clinical lymphoma fellowship with BC Cancer in Vancouver. Her practice focuses on lymphoma and chronic lymphocytic leukemia.


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How to Cite

Murphy S. Frontline treatment of aggressive B-cell lymphoma. Can Hematol Today [Internet]. 2023 Nov. 6 [cited 2024 Jun. 19];2(3):28-31. Available from: