Frontline Treatment of Aggressive B-cell Lymphoma
Aggressive B-cell non-Hodgkin lymphoma, which most often manifests as diffuse large B-cell lymphoma (DLBCL), is the most common non-Hodgkin lymphoma, accounting for up to 30% of diagnosed cases. It is responsible for considerable morbidity and mortality worldwide, with a global burden of approximately 150,000 new patients annually. Large B-cell lymphoma encompasses a group of lymphomas with significant clinical and biological heterogeneity. While there are approximately 18 variations of large B-cell lymphoma in the upcoming 5th edition of the World Health Organization classification of lymphoid neoplasms (WHO-HAEM5), for the purposes of this review the aggressive B-cell lymphomas will refer to the most common entity, diffuse large B-cell lymphoma, not otherwise specified (DLBCL), as well as diffuse large B-cell lymphoma/high-grade B-cell lymphoma with MYC and BCL2 rearrangements (DLBCL/HGBL-MYC/BCL2), and high-grade B-cell lymphoma, not otherwise specified (HGBL,NOS).
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