Bispecific antibodies and chimeric antigen receptor (CAR) T-cell therapy for indolent lymphoma

Authors

  • Isabelle Fleury, MD University of Montreal, Maisonneuve-Rosemont Hospital
  • Eva Laverdure, MD University of Montreal, Maisonneuve-Rosemont Hospital

DOI:

https://doi.org/10.58931/cht.2023.2338

Abstract

Classic follicular (FL) and marginal zone (MZL) lymphomas are the primary indolent non-Hodgkin lymphomas (iNHL). Once first-line therapy is initiated, the majority of patients eventually experience treatment failure and face progressively shorter disease-free periods following subsequent lines of conventional chemotherapy. Patients with progressive disease within 24 months of first-line therapy (POD24) represent a significant unmet need. The five-year overall survival (OS) for patients with FL and POD24 is only 50% vs 90% for those without POD24. The three-year OS for patients with MZL is 53% and 95% respectively.

Author Biographies

Isabelle Fleury, MD, University of Montreal, Maisonneuve-Rosemont Hospital

Dre Isabelle Fleury is a hematologist and a medical oncologist working at Maisonneuve‑Rosemont Hospital in Montreal. She is a Clinical Associate Professor at the University of Montreal and is the Program Director of the fellowship in lymphoma and immune effector cells at University of Montreal. Her main interest is improving the care of patients with lymphoma. She is the Medical Lead of the lymphoma clinic at Maisonneuve Rosemont Hospital. She contributes to clinical research in lymphoma through participating in phase 1 to 3 trials. She is the instigator of the C3i Lymphoma Registry collecting clinical and bio clinical data to better understand lymphoma in the real-world setting. She participates in clinical trials of immune effector cells, is actively involved in the implementation of CAR-T in clinical practice in Quebec and is the medical lead of the Quebec immunocellular therapy network.

Eva Laverdure, MD, University of Montreal, Maisonneuve-Rosemont Hospital

Dre Eva Laverdure is a hematologist from the University of Sherbrooke with an interest in lymphoma and CAR-T cell therapy. She is currently consolidating her expertise through a fellowship in lymphoma and immune effector cells at Maisonneuve-Rosemont Hospital with the University of Montreal. 

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Published

2023-11-06

How to Cite

1.
Fleury I, Laverdure E. Bispecific antibodies and chimeric antigen receptor (CAR) T-cell therapy for indolent lymphoma. Can Hematol Today [Internet]. 2023 Nov. 6 [cited 2024 Jun. 19];2(3):5-11. Available from: https://canadianhematologytoday.com/article/view/2-3-fleury_laverdure

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