L’entretien dans les lymphomes indolents CD20+ : Qui devrait en recevoir?
Résumé
Depuis vingt au Canada, l’entretien au rituximab (ER) est un pilier du traitement du lymphome indolent CD20-positif (+). L’adoption de l’ER dans la pratique clinique a eu lieu après la publication de l’essai EORTC 20981. Cet essai a montré une amélioration significative de la survie sans progression (SSP) avec deux ans d’ER par rapport à l’observation, suite à un traitement d’induction par CHOP (cyclophosphamide, doxorubicine, vincristine et prednisone) ou R-CHOP (rituximab, cyclophosphamide, doxorubicine, vincristine et prednisone) chez les patients atteints d’un lymphome folliculaire (LF) récidivant. L’utilisation de l’ER a été largement étendue pour inclure son emploi en première ligne de traitement, après toutes les inductions contenant du rituximab et pour toutes les histologies de lymphomes indolents CD20-positifs.
Une recommandation automatique pour un ER était devenue la pratique standard pour la plupart des patients. Toutefois, compte tenu des récentes modifications apportées aux schémas d’induction standard dans certaines indications et des préoccupations accrues concernant les complications infectieuses au cours d’un traitement entraînant une déplétion des lymphocytes B, la recommandation d’utiliser l’entretien au R ne devrait plus être considérée comme automatique. Cette revue offre une perspective nuancée des données probantes concernant l’entretien avec le rituximab.
Références
van Oers MH, Van Glabbeke M, Giurgea L, et al. Rituximab maintenance treatment of relapsed/resistant follicular non-Hodgkin's lymphoma: long-term outcome of the EORTC 20981 phase III randomized intergroup study. J Clin Oncol. 2010;28(17):2853-2858. doi:10.1200/JCO.2009.26.5827
Le M, Ghazawi FM, Alakel A, Netchiporouk E, Rahme E, Zubarev A, et al. Incidence and mortality trends and geographic patterns of follicular lymphoma in Canada. Curr Oncol. 2019;26(4):e473-e481. doi: 10.3747/co.26.4625
Bachy E, Seymour JF, Feugier P, Offner F, López-Guillermo A, Belada D, et al. Sustained progression-free survival benefit of rituximab maintenance in patients with follicular lymphoma: long-term results of the PRIMA study. J Clin Oncol. 2019;37(31):2815-2824. doi:10.1200/JCO.19.01073
Flinn IW, van der Jagt R, Kahl B, Wood P, Hawkins T, MacDonald D, et al. First-line treatment of patients with indolent non-Hodgkin lymphoma or mantle-cell lymphoma with bendamustine plus rituximab versus R-CHOP or R-CVP: results of the BRIGHT 5-year follow-up study. J Clin Oncol. 2019;37(12):984-991. doi:10.1200/JCO.18.00605
Rummel MJ, Maschmeyer G, Ganser A, Heider A, von Gruenhagen U, Losem C, et al. Bendamustine plus rituximab (B-R) versus CHOP plus rituximab (CHOP-R) as first-line treatment in patients with indolent lymphomas: nine-year updated results from the StiL NHL1 study. J Clin Oncol. 2017;35(15_suppl):7501. doi: 10.1200/JCO.2017.35.15_suppl.7501
Kahl BS, Burke JM, van der Jagt R, Chang J, Wood P, Hawkins TE, et al. Assessment of maintenance rituximab after first-line bendamustine-rituximab in patients with follicular lymphoma: an analysis from the BRIGHT trial. Blood. 2017;130 (Supplement 1):484. doi: 10.1182/blood.V130.Suppl_1484.1484
Hill BT, Nastoupil LJ, Winter A, Becnel M, Cerhan JR, Habermann TM, et al. Maintenance rituximab or observation after frontline treatment with bendamustine‐rituximab for follicular lymphoma. Br J Haematol. 2018;184(4):524-535. doi: 10.1111/bjh.15720
Rummel M, Buske C, Hertenstein B, Lerchenmüller C, Koenigsmann M, Lange E, et al. Four versus two years of rituximab maintenance (R-maintenance) following bendamustine plus rituximab (B-R): initial results of a prospective, randomized multicenter phase 3 study in first-line follicular lymphoma (the StiL NHL7-2008 MAINTAIN study). Blood. 2018;130 (Supplement 1):483. doi: 10.1182/blood.V130.Suppl_1.483.483
Sarkozy C, Maurer MJ, Link BK, Ghesquieres H, Nicolas E, Thompson CA, et al. Cause of death in follicular lymphoma in the first decade of the rituximab era: a pooled analysis of French and US Cohorts. J Clin Oncol. 2019;37(2):144-152. doi: 10.1200/JCO.18.00400
Townsend W, Hiddemann W, Buske C, Cartron G, Cunningham D, Dyer MJ, et al. Obinutuzumab versus rituximab immunochemotherapy in previously untreated iNHL: final results from the GALLIUM study. Hemasphere. 2023;7(7):e919. doi:10.1097/HS9.0000000000000919
Suleman A, Aktar SJ, Ante Z, Liu N, Chan K, Cheung MC, et al. Outcomes of patients with indolent lymphoma treated with bendamustine plus rituximab compared to rituximab plus CVP or CHOP chemoimmunotherapy in Ontario. Br J Haematol. 2023;202(6):1104-1118. doi: 10.1111/bjh.18972
Kahl BS, Jegede O, Peterson CG, Swinnen LJ, Habermann TM, Schuster SJ, et al. Long-term follow-up of the RESORT study (E4402): a randomized phase III comparison of two different rituximab dosing strategies for low–tumor burden follicular lymphoma. J Clin Oncol. 2024;42(7):774-778. doi:10.1200/JCO.23.01912
Kluin‐Nelemans HC, Hoster E, Hermine O, Walewski J, Geisler CH, Trneny M, et al. Treatment of older patients with mantle cell lymphoma (MCL): long-term follow-up of the randomized European MCL Elderly trial. J Clin Oncol. 2020;38(3):248-256. doi: 10.1200/JCO.19.01294
Martin P, Cohen JB, Wang M, Kumar A, Hill B, Villa D, et al. Treatment outcomes and roles of transplantation and maintenance rituximab in patients with previously untreated mantle cell lymphoma: results from large real-world cohorts. J Clin Oncol. 2023;41(3):541-554. doi:10.1200/JCO.21.02698
Sarkozy C, Thieblemont C, Obéric L, Moreau A, Bouabdallah K, Damaj G, et al. Very long-term follow-up of rituximab maintenance in young patients with mantle cell lymphoma included in the LYMA trial, a LYSA study. J Clin Oncol. 2024;42(7):769-773. doi:10.1200/JCO.23.01586
Vidal L, Gafter‐Gvili A, Dreyling M, Ghielmini M, Witzens‐Harig M, Shpilberg O, et al. Maintenance treatment for patients with mantle cell lymphoma. Hemasphere. 2018;2(4):e136. doi:10.1097/HS9.0000000000000136
Saurabh Zanwar, Abeykoon JP. Treatment paradigm in Waldenström macroglobulinemia: frontline therapy and beyond. Ther Adv Hematol. 2022;13:20406207221093962. doi:10.1177/20406207221093962
Rummel MJ, Lerchenmuller CA, Hensel M, Goerner M, Buske C, Schulz H, et al. Two years rituximab maintenance vs. observation after first line treatment with bendamustine plus rituximab (B-R) in patients with Waldenström’s macroglobulinemia (MW): results of a prospective, randomized, multicenter phase 3 study (the StiL NHL7-2008 MAINTAIN trial). Blood. 2019;134(Supplement_1):343. doi: 10.1182/blood-2019-121909
Williams ME, Hong F, Gascoyne RD, Wagner LI, Krauss JC, Habermann TM, et al. Rituximab extended schedule or retreatment trial for low tumour burden non-follicular indolent B-cell non-Hodgkin lymphomas: Eastern Cooperative Oncology Group Protocol E4402. Br J Haematol. 2016;173(6):867-875. doi: 10.1111/bjh.14007
Wirth SRM, Podar K, Pecherstorfer M, Wohlfarth P, Jaeger U, Singer J. Evaluation of antibody responses in patients with B-Cell malignancies after two and three doses of Anti-SARS-CoV-2 S vaccination-a retrospective cohort study. Cancers (Basel). 2023;15(2):524. doi: 10.3390/cancers15020524
Liatsou E, Ntanasis-Stathopoulos I, Lykos S, Ntanasis-Stathopoulos A, Gavriatopoulou M, Psaltopoulou T, et al. Adult patients with cancer have impaired humoral responses to complete and booster COVID-19 vaccination, especially those with hematologic cancer on active treatment: a systematic review and meta-analysis. Cancers (Basel). 2023;15(8):2266. doi: 10.3390/cancers15082266
Duléry R, Lamure S, Delord M, Di Blasi R, Chauchet A, Hueso T, et al. Prolonged in-hospital stay and higher mortality after Covid-19 among patients with non-Hodgkin lymphoma treated with B-cell depleting immunotherapy. Am J Hematol. 2021;96(8):934-944. doi: 10.1002/ajh.26209
Kow CS, Ramachandram DS, Hasan SS, Thiruchelvam K. Systematic review and meta-analysis of anti-CD20 treatments in patients with COVID-19: an assessment of severe illness and mortality outcomes. Inflammopharmacology. 2023;31(6):3339-3355. doi: 10.1007/s10787-023-01349-z
Publié
Comment citer
Numéro
Rubrique
Licence
© Actualité hématologique au Canada 2024
Cette œuvre est sous licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.
