Les inhibiteurs de tyrosine kinase pour la prise en charge de la LMC en première intention de traitement : une vue d’ensemble
Résumé
L’introduction des inhibiteurs de tyrosine kinase (ITK) dans le traitement de la leucémie myéloïde chronique (LMC) a révolutionné le traitement de cette maladie. Ces agents ont augmenté l’espérance de vie des patients atteints de LMC à 98 % de celle de la population générale. Depuis la première approbation de l’imatinib pour le traitement de la LMC (par la FDA américaine en 2001), trois autres ITK ont été approuvés pour le traitement de première ligne de la LMC en phase chronique (PC), soient : le dasatinib, le nilotinib et le bosutinib. Cet article discutera des étapes initiales pour les patients atteints de LMC nouvellement diagnostiquée, des traitements de 1re intention et de sa prise en charge.
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