Prise en charge du myélome multiple nouvellement diagnostiqué inadmissible à une greffe (MMNDIG) en première ligne de traitement
Résumé
Le myélome multiple (MM) est un cancer hématologique malin caractérisé par une prolifération clonale de plasmocytes dans la moelle osseuse entraînant un dysfonctionnement des organes, notamment une hypercalcémie, une anémie, un dysfonctionnement rénal et/ou des lésions lytiques osseuses. L’âge médian du diagnostic est de 69 ans et environ un tiers des patients nouvellement diagnostiqués ont plus de 75 ans. Par conséquent, une partie importante des patients présentant un MM nouvellement diagnostiqué sont considérés comme inadmissibles à une greffe (IG) en raison de leur âge chronologique, de leurs comorbidités ou de leur fragilité. Cette catégorie de patients représentante un groupe de patients largement hétérogène. Les options thérapeutiques en première ligne évoluent rapidement, les médecins doivent donc s’interroger sur la modalité de traitement optimale.
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